Mara's owner is killed while illegally hunting a rhino, and the new manager Cedric Fatani seems even more intent on causing mayhem, as he diverts water from the shared spring, causing the death of many Leopards Den animals.

Series 2 (2007): The Trevanions struggle financially and attempt to satisfy their first guests' desire for acceptable accommodations and game drives. They face many challenges, including a deadly snakebite, an anthrax outbreak that threatens the reserve's stock starving lions runaway children uninvited guests and competition from Mara, the larger game park next door whose owner, Alex Tate, doesn't share Danny's values and tries to make a move on Sarah. The Trevanions begin settling into life in the African bush, and Danny grows into his role as a gifted vet treating stray cheetahs, elephants, etc. He persuades them to stay and enter into a business partnership to restore the property as a game reserve for wild animals. Arriving at Leopards Den, they meet Anders Du Plessis ('Dup') whose family has owned the property for over 100 years.

His wife Sarah suggests a family vacation to Africa to rehabilitate it. Series 1 (2006): The Trevanion family is introduced at home in Bristol, England, where an abandoned vervet monkey is brought into Danny's veterinary surgery.

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